Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles

Author:

Mejías Raquel1,Pérez-Yagüe Sonia1,Roca Alejandro G2,Pérez Nicolás3,Villanueva Ángeles4,Cañete Magdalena4,Mañes Santos1,Ruiz-Cabello Jesús5,Benito Marina6,Labarta Amilcar3,Batlle Xavier3,Veintemillas-Verdaguer Sabino2,Morales M Puerto2,Barber Domingo F1,Serna Carlos J2

Affiliation:

1. Centro Nacional de Biotecnología/CSIC, Spain

2. Instituto de Ciencia de Materiales de Madrid/CSIC, Sor Juana Inés de la Cruz 3, Campus de Cantoblanco, Madrid 28049, Spain.

3. Universitat de Barcelona, Spain

4. Universidad Autónoma de Madrid, Madrid, Spain

5. Universidad Complutense de Madrid & CIBER de Enfermedades Respiratorias, Madrid, Spain

6. Hospital Gregorio Marañón, Madrid, Spain

Abstract

Background & aim: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. Material & method: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. Results: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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