Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host

Author:

Speziale Pietro1,Pietrocola Giampiero1,Rindi Simonetta1,Provenzano Maria1,Provenza Giulio1,Di Poto Antonella1,Visai Livia2,Arciola Carla Renata3

Affiliation:

1. Department of Biochemistry, Viale Taramelli 3/b 27100 Pavia, Italy.

2. Department of Biochemistry, Viale Taramelli 3/b 27100 Pavia, Italy and Center for Tissue Engineering (CIT), Via Ferrata 1, 27100 Pavia, Italy.

3. Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Via di Barbiano 1/10, 40136 Bologna, Italy and Experimental Pathology Department, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy.

Abstract

Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Reference128 articles.

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2. ProjanJ, Novick R: The molecular basis of pathogenicity. In:The Staphylococci in Human Disease. Grossley KB, Archer GL(Eds). Churchill Livingstone, NY, USA,55–81 (1997).

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