Biochemical markers in Alzheimer’s disease clinical trials-Reference-Cited by-同舟云学术

Biochemical markers in Alzheimer’s disease clinical trials

Published:2010-02 Issue:1 Volume:4 Page:91-98
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zetterberg Henrik¹,Mattsson Niklas¹,Shaw Les M²,Blennow Kaj¹

Affiliation:

1. Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, S-431 80 Mölndal, Sweden.

2. Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

Abstract

This article summarizes how biochemical markers may aid in the development of novel treatments that interfere with fundamental pathogenic processes in Alzheimer’s disease. Details are given on the potential use of biomarkers in Alzheimer’s disease clinical trials as additional inclusion criteria to enrich study populations with participants who really suffer from the disease, as a means to stratify study participants into meaningful subgroups that may benefit differently from the treatment, and as tools to detect desired biochemical effects and undesired side effects of the drug.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.09.80

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