Performance of the Alere™ i Influenza A&B and the Cepheid Xpert® Flu/RSV XC assays-Reference-Cited by-同舟云学术

Performance of the Alere™ i Influenza A&B and the Cepheid Xpert® Flu/RSV XC assays

Published:2017-06 Issue:6 Volume:12 Page:251-259
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Zelyas Nathan¹,Shokoples Sandy¹,Droogers Joel²,Lundeberg Roberta¹,Leedell Duane²,Drews Steven J¹²

Affiliation:

1. ProvLab Alberta, Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112 St, Edmonton, AB T6G 2J2, Canada

2. Department of Laboratory Medicine & Pathology, University of Alberta, 8440 112 St NW, Edmonton, AB T6G 2R7, Canada

Abstract

Aim: To evaluate the Alere™ i Influenza A&B assay and the Xpert® Flu/RSV XC assay using nasopharyngeal aspirates and swabs not provided in the commercial kits. Methods: Specimens were tested with the Alere i Influenza A&B and the Xpert Flu/RSV XC assays and compared with reference methods. Results: Compared with the comparator methods and following discordant analysis, the sensitivity of the i Influenza A&B assay was 63.3% for influenza A and 83.3% for influenza B. For the Xpert Flu/RSV XC assay, sensitivity was 100% for influenza A and B and respiratory syncytial virus. The specificity for all test systems was 100%. Conclusion: The Xpert Flu/RSV XC assay out-performed the Alere i Influenza A&B assay in all diagnostic characteristics evaluated.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2017-0002

Reference19 articles.

1. Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

2. Comparison of the IMDx Influenza A Virus, Influenza B Virus, and Respiratory Syncytial Virus A/B Assay on the m2000 Platform with Real-Time Reverse Transcriptase PCR Assays

3. Comparison of the Luminex xTAG Respiratory Viral Panel with xTAG Respiratory Viral Panel Fast for Diagnosis of Respiratory Virus Infections

4. Alere™ product insert. i Influenza A&B. MA, USA (2015).

5. Cepheid®product insert. Xpert®Flu/RSV XC. CA, USA (2014).

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