Role of interferon-stimulated genes in regulation of HCV infection and type I interferon anti-HCV activity-Reference-Cited by-同舟云学术

Role of interferon-stimulated genes in regulation of HCV infection and type I interferon anti-HCV activity

Published:2018-04-01 Issue:5 Volume:13 Page:353-359
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Liao Xinzhong¹,Wang Yancui¹,Ye Haiyan¹,Li Shilin¹,Chen Limin¹,Duan Xiaoqiong¹

Affiliation:

1. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, 610052 Chengdu, PR China

Abstract

HCV chronically infects over 71 million people worldwide and is one of the leading causes of advanced liver diseases. Type I interferons (IFN-α/β) play critical role in host antiviral innate immunity. IFN-α/β exerts its anti-HCV effects through the activation of the JAK/STAT signaling pathway leading to the induction of a few hundred interferon-stimulated genes (ISGs). The interplay between ISG and HCV infection remains partially understood. In this review, we summarized the role of ISGs in HCV infection and interferon anti-HCV activity.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2017-0160

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