Cardiac MRI biomarkers for Duchenne muscular dystrophy-Reference-Cited by-同舟云学术

Cardiac MRI biomarkers for Duchenne muscular dystrophy

Published:2018-11 Issue:11 Volume:12 Page:1271-1289
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Magrath Patrick¹²,Maforo Nyasha¹³,Renella Pierangelo¹⁴,Nelson Stanley F⁵,Halnon Nancy¹⁶,Ennis Daniel B¹²³

Affiliation:

1. Department of Radiological Sciences, University of California, Los Angeles, CA 90024, USA

2. Department of Bioengineering, University of California, Los Angeles, CA 90095, USA

3. Physics & Biology in Medicine IDP, University of California, Los Angeles, CA 90095, USA

4. Department of Medicine, Division of Pediatric Cardiology, CHOC Children's Hospital, Orange, CA 92868, USA

5. Center for Duchenne Muscular Dystrophy, Department of Human Genetics, University of California, Los Angeles, CA 90095, USA

6. Department of Medicine, Division of Pediatric Cardiology, University of California, Los Angeles, CA 90024, USA

Abstract

Duchenne muscular dystrophy (DMD) is a fatal inherited genetic disorder that results in progressive muscle weakness and ultimately loss of ambulation, respiratory failure and heart failure. Cardiac MRI (MRI) plays an increasingly important role in the diagnosis and clinical care of boys with DMD and associated cardiomyopathies. Conventional cardiac MRI biomarkers permit measurements of global cardiac function and presence of fibrosis, but changes in these measures are late manifestations. Emerging MRI biomarkers of myocardial function and structure include the estimation of rotational mechanics and regional strain using MRI tagging; T1-mapping; and T2-mapping, a marker of inflammation, edema and fat. These emerging biomarkers provide earlier insights into cardiac involvement in DMD, improving patient care and aiding the evaluation of emerging therapies.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0125

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