Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation-Reference-Cited by-同舟云学术

Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation

Published:2013-12 Issue:6 Volume:7 Page:947-957
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Dedeoglu Burç¹,de Geus Hilde RH²,Fortrie Gijs¹,Betjes Michiel GH³

Affiliation:

1. Department of Nephrology, Erasmus University Medical Center, Rotterdam, The Netherlands

2. Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands

3. Erasmus Medical Center, Department of Nephrology & Transplantation, H438, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

Abstract

Aim: Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. Materials & methods: Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured at four different time points during an intensive care unit admission. Results: Plasma NGAL detected AKI with an optimal area under the curve at 8 h after admission (0.86; p = 0.004) and at 4 h after admission for urinary NGAL (0.80; p = 0.012). The other markers failed to detect AKI. Conclusion: NGAL is a promising biomarker for detecting AKI in patients after liver transplantation.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.13.91

Reference34 articles.

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3. Neutrophil Gelatinase-associated Lipocalin at ICU Admission Predicts for Acute Kidney Injury in Adult Patients

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5. N-GAL: Diagnosing AKI as soon as possible

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