The importance of nonpharmacogenetic factors in endocrine therapy-Reference-Cited by-同舟云学术

The importance of nonpharmacogenetic factors in endocrine therapy

Published:2012-04 Issue:6 Volume:13 Page:721-728
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

McCowan Colin¹,Thompson Alastair M²

Affiliation:

1. Dundee Cancer Centre, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK

2. Dundee Cancer Centre, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK.

Abstract

Nonpharmacogenetic factors may play a key role in the success of oral endocrine therapy for breast cancer. Adherence, defined as following medical advice as well as persistence and duration of use for patients prescribed endocrine therapy, may impact significantly on recurrence and survival. Side effects from tamoxifen or aromatase inhibitors may lead to patients stopping or switching therapy, while comorbidities, consequent coprescribing and patient perceptions may also influence outcomes. Interventions to improve adherence and persistence are required and could have as great an effect on survival as applying pharmacogenetic principles to the endocrine management of breast cancer.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.12.29

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