Genetics and antiepileptic mood stabilizer treatment response in bipolar disorder: what do we know?

Author:

Ho Ada Man-Choi1ORCID,Weinshilboum Richard M2ORCID,Frye Mark A1,Biernacka Joanna M13ORCID

Affiliation:

1. Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN 55905, USA

2. Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA

3. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA

Abstract

Antiepileptic mood stabilizers (AED-MS) are often used to treat bipolar disorder (BD). Similar to other mood disorder medications, AED-MS treatment response varies between patients. Identification of biomarkers associated with treatment response may ultimately help with the delivery of individualized treatment and lead to improved treatment efficacy. Here, we conducted a narrative review of the current knowledge of the pharmacogenomics of AED-MS (valproic acid, lamotrigine and carbamazepine) treatment response in BD, including genetic contributions to AED-MS pharmacokinetics. Genes involved in neurotransmitter systems and drug transport have been shown to be associated with AED-MS treatment response. As more studies are conducted, and experimental and analytical methods advance, knowledge of AED-MS pharmacogenomics is expected to grow and contribute to precision medicine in BD.

Funder

Gift from Kent and Liz Dauten to Mayo Clinic

Mayo Clinic Center for Individualized Medicine

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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