Pharmacogenetics research in Brazil: a systematic review-Reference-Cited by-同舟云学术

Pharmacogenetics research in Brazil: a systematic review

Published:2022-03 Issue:4 Volume:23 Page:263-275
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Torres-Loureiro Sabrina¹^ORCID,Scudeler Mariana M¹^ORCID,Andrade Poliana XC²,Sampaio-Coelho Julia²³,Nobre Igor H¹,Céspedes-Garro Carolina⁴^ORCID,Tarazona-Santos Eduardo²⁵⁶^ORCID,Llerena Adrián⁵⁷^ORCID,Rodrigues-Soares Fernanda¹⁵^ORCID

Affiliation:

1. Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, 38025-350, Brazil

2. Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-910, Brazil

3. Residência Médica de Pediatria do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil

4. Genetics Section, School of Biology, University of Costa Rica, San Pedro, San José 11501, Costa Rica

5. RIBEF Ibero-American Network of Pharmacogenetics & Pharmacogenomics, Badajoz, Extremadura, Spain

6. Universidad Peruana Cayetano Heredia, Lima, 15102, Peru

7. Instituto de Investigación Biosanitaria de Extremadura, Universidad de Extremadura, SES, Badajoz, Extremadura, Spain

Abstract

Aim: Pharmacogenomics (PGx) is a rising scientific area in many countries, such as Brazil. Objectives: To identify biomarkers, therapeutic areas, probe drugs and regions/ethnicities most studied in the country in order to guide future studies. Materials & methods: Systematic review of 1060 studies (from 1968 to 2020) comprising 80 genes, six probe drugs and 3,819,233 individuals. Results: MTHFR and HLA-A/B were the most studied genes and metoprolol and dextromethorphan the most studied probe drugs. Oncology was the most studied therapeutic area considering PGx biomarkers. The country’s regions and ethnic groups were studied unevenly, with south/southeast and White people over-represented in respect to their demographic relevance, in detriment of the center-west/northeast/north and Black/mixed individuals. Conclusion: Many of the gaps and possible paths to be covered to reach even PGx data are pointed out by this review.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Junta de Extremadura-AEXCID

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2021-0128

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