Effects of MDR1 and OPRM1 genetic polymorphisms on the pharmacodynamics of propofol–remifentanil TIVA in pediatrics

Author:

Liew Yee1ORCID,Capule Francis R2ORCID,Rahman Raha Abdul3ORCID,Nor Nadia Md3ORCID,Teo Rufinah3ORCID,Makmor-Bakry Mohd1ORCID

Affiliation:

1. Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia

2. College of Pharmacy, University of the Philippines, Manilla, 1000, Philippines

3. Department of Anesthesiology & Intensive Care, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaakob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur, 56000, Malaysia

Abstract

Aims: To investigate the roles of MDR1 ( 1236C>T, 2677G>T/A, and 3435C>T) and OPRM1 ( 118A>G) gene polymorphisms on the anesthetic and adverse effects of propofol–remifentanil total intravenous anesthesia in pediatric surgery. Materials & methods: The genotypes were identified through Sanger sequencing. The clinical data including hemodynamics on anesthesia, postanesthesia pain and sedation score and the occurrence of adverse effects were recorded and compared against the genetic data. Results: A total of 72 pediatric patients undergoing surgery were recruited. A weak to no association was found between the genetic polymorphisms of MDR1 and OPRM1 and the anesthetic and adverse effects of propofol–remifentanil. Conclusion: Genetic polymorphisms in OPRM1, but not in MDR1, gene polymorphism, demonstrated plausible association with the effects of propofol–remifentanil.

Funder

Fundamental Research Grant Scheme, Malaysian Ministry of Higher Education

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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