<i>UGT1A1</i> genotype-guided dosing of irinotecan: time to prioritize patient safety-Reference-Cited by-同舟云学术

UGT1A1 genotype-guided dosing of irinotecan: time to prioritize patient safety

Published:2023-06 Issue:8 Volume:24 Page:435-439
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Peeters Sofía LJ¹²^ORCID,Deenen Maarten J¹²,Thijs Anna MJ³,Hulshof Emma C¹²^ORCID,Mathijssen Ron HJ⁴^ORCID,Gelderblom Hans⁵^ORCID,Guchelaar Henk-Jan²^ORCID,Swen Jesse J²^ORCID

Affiliation:

1. Department of Clinical Pharmacy, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands

2. Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

3. Department of Medical Oncology, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands

4. Department of Medical Oncology, Erasmus University Medical Centre, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands

5. Department of Medical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

Abstract

Tweetable abstract Pretreatment UGT1A1 genotyping and a 70% irinotecan dose intensity in poor metabolizers is safe, feasible, cost-effective and essential for safe irinotecan treatment in cancer patients. It is time to update guidelines to swiftly enable the implementation of UGT1A1 genotype-guided irinotecan dosing in routine oncology care.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2023-0096

Reference32 articles.

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2. Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

3. All You Need to Know About UGT1A1 Genetic Testing for Patients Treated With Irinotecan: A Practitioner-Friendly Guide

4. Genetic Variants in theUDP-glucuronosyltransferase 1A1Gene Predict the Risk of Severe Neutropenia of Irinotecan

5. Irinogenetics: How Many Stars Are There in the Sky?

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