Copy number variants and pharmacogenomics-Reference-Cited by-同舟云学术

Copy number variants and pharmacogenomics

Published:2006-01 Issue:1 Volume:7 Page:25-29
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Ouahchi Karim¹²,Lindeman Neal¹²,Lee Charles¹²

Affiliation:

1. Brigham and Women’s Hospital, Department of Pathology, 20 Shattuck Street, Thorn 612A, Boston, MA 02115, USA.

2. Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA

Abstract

The earliest pharmacogenomic studies focused on highly penetrant sequence polymorphisms in drug-metabolizing enzymes. The recent discovery of the widespread occurrence of copy number variants/polymorphisms in the human genome holds promise for new pharmacogenomic discoveries, aside from the commonly used single nucleotide polymorphism approach. Here we review the discovery of copy number variants and speculate on their implications for pathophysiology and pharmacogenomics.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/14622416.7.1.25

Reference26 articles.

1. The Hemolytic Effect of Primaquine and Related Compounds: a Review

2. Genetic Control of Isoniazid Metabolism in Man

3. Pharmacogenomics of blood pressure response to antihypertensive treatment

4. Neuropsychiatric pharmacogenetics: moving toward a comprehensive understanding of predicting risks and response

5. Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity

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