The pharmacogenetics of coumarin therapy-Reference-Cited by-同舟云学术

The pharmacogenetics of coumarin therapy

Published:2005-07 Issue:5 Volume:6 Page:503-513
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Voora Deepak¹,McLeod Howard L¹,Eby Charles¹,Gage Brian F¹²

Affiliation:

1. Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO, USA

2. Washington University School of Medicine, Division of General Medical Sciences, Campus Box 8005, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.

Abstract

Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/14622416.6.5.503

Reference103 articles.

1. Genetic mechanisms for hypersensitivity and resistance to the anticoagulant Warfarin

2. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin1 1No competing interests declared.

3. Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin

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