Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel-Reference-Cited by-同舟云学术

Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel

Published:2007-07 Issue:7 Volume:8 Page:803-815
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Steed Helen¹,Sawyer Michael B²³

Affiliation:

1. University of Alberta, Department of Gyne-oncology, Department of Obstetrics and Gynecology, Cross Cancer Institute, Edmonton, Alberta, Canada

2. University of Alberta, Department of Medical Oncology, Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada

3. University of Alberta, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada.

Abstract

Paclitaxel is widely used in many cancers including ovarian, breast, lung, head and neck and primary unknown. Paclitaxel is extensively metabolized by cytochrome P450s and excreted in bile. The cytochromes involved include 2C8 and 3A4. This is a review of the pharmacokinetics, pharmacodynamics, drug interactions, metabolism and pharmacogenomics of paclitaxel.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/14622416.8.7.803

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