Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example
Author:
Affiliation:
1. GlaxoSmithKline Genetics, 5 Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA.
2. Infectious Diseases Medicines Development Centre, USA
3. Infectious Diseases Centre of Excellence in Drug Discovery, USA
Abstract
Publisher
Future Medicine Ltd
Subject
Pharmacology,Genetics,Molecular Medicine
Link
https://www.futuremedicine.com/doi/pdf/10.2217/14622416.10.2.225
Reference30 articles.
1. Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility
2. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir
3. Updated clinical risk factor analysis of suspected hypersensitivity reactions to abacavir
4. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
5. Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
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