Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae-Reference-Cited by-同舟云学术

Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae

Published:2015-10 Issue:10 Volume:10 Page:1609-1613
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Grosso Filipa¹,Silva Liliana¹²,Sousa Clara³,Ramos Helena⁴,Quinteira Sandra⁵⁶⁷,Peixe Luísa¹

Affiliation:

1. UCIBIO-REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050–313 Porto, Portugal

2. Escola Superior de Saúde Dr. Lopes Dias, Instituto Politécnico de Castelo Branco, Castelo Branco, Portugal

3. CEB- Centro de Engenharia Biológica, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

4. Hospital Geral de Santo António, Porto, Portugal

5. CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos. Universidade do Porto (CIBIO/UP)/InBio Laboratório Associado, Vairão, Portugal

6. Faculdade de Ciências da Universidade do Porto, Departamento de Biologia, Porto, Portugal

7. CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal

Abstract

Aim: Acinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates. Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations. Results: Isolates were not clonally related but both produced the ‘exclusively Portuguese’ IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located. Conclusion: Our results emphasize the role of non-baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogens.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb.15.88

Reference24 articles.

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