Plasma S100A4 level and cardiovascular risk in patients with unstable angina pectoris-Reference-Cited by-同舟云学术

Plasma S100A4 level and cardiovascular risk in patients with unstable angina pectoris

Published:2019-12 Issue:17 Volume:13 Page:1459-1467
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Yang Le¹,Song Liang²,Ma Danfeng³,Zhang Jingjing⁴,Xie Hao⁵,Wu Hongpeng⁶,Liu Hang⁷,Yu Shuang⁸,Liang Hengyi¹,Zhang Pu⁹,Cui Lianqun¹,Yuan Haitao¹,Chen Liming¹

Affiliation:

1. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Shandong, PR China

2. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, PR China

3. Department of Vascular Surgery, Shandong Provincial Hospital affiliated to Shandong University, Shandong, PR China

4. Department of Obstetrics, Weifang Yidu Central Hospital, Shandong, PR China

5. Department of Cardiology, Nanjing Drum Tower Hospital, Jiangsu, PR China

6. Department of Medical Imaging, Shandong Provincial Hospital affiliated to Shandong University, Shandong, PR China

7. Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Henan, PR China

8. Department of Cardiology, Zibo Zhoucun People's Hospital, Shandong, PR China

9. Department of Cardiology, Taian City Central Hospital, Shandong, PR China

Abstract

Aim: We investigated whether S100A4 level is associated with pathophysiology of unstable angina pectoris (UAP), and its potential prognostic value for subsequent cardiovascular events. Methods: We compared plasma levels of S100A4 and a set of clinical markers in three groups (59 with UAP, 32 with stable angina pectoris and 30 healthy controls). Results: S100A4 levels in patients with UAP were significantly elevated. In UAP group, baseline S100A4 levels were significantly higher in patients with subsequent cardiovascular events than those without, a positive correlation was identified between the risk of subsequent cardiovascular events and the plasma levels of S100A4. Conclusion: Elevated S100A4 levels may be involved in the pathogenesis of UAP, and may be a marker predictive of post-treatment cardiovascular events.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0137

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