Serum DKK1 is correlated with γ peak of serum electrophoresis in multiple myeloma: a multicenter biomarker study-Reference-Cited by-同舟云学术

Serum DKK1 is correlated with γ peak of serum electrophoresis in multiple myeloma: a multicenter biomarker study

Published:2019-10 Issue:15 Volume:13 Page:1297-1306
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Hashemi Zahra Sadat¹,Khalili Saeed²³^ORCID,Malaei Fatemeh²,Mard-Soltani Maysam⁴,Jafarisani Moslem⁵,Lotfi Jabar⁶,Deemeh Mohammad Reza⁶,Zakeri Alireza³,Rasaee Mohamad Javad²

Affiliation:

1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran

2. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

3. Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran

4. Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran

5. Clinical Biochemistry, Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

6. Department of Clinical Biochemistry, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran

Abstract

Aim: DKK1 is reported to be produced at high levels by myeloma cells. Therefore, the applicability of DKK1 as a tumor marker for multiple myeloma (MM) diagnosis was examined. Methods: Serum samples were collected and analyzed by DKK1 concentration kit and capillary zone electrophoresis. Then, the obtained results were statically analyzed. Results: It has been determined that the 10 ng/ml of DKK1 is the optimal level for MM diagnosis. Moreover, there was an ascending linear correlation between the DKK1 concentration and γ peak. Discussion: The observed correlation could be rooted in the positive feedback loop between MM cells and the mesenchymal stem cells. In view of these results, DKK1 could be deemed as diagnostic marker for MM.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0060

Reference48 articles.

1. Multiple Myeloma

2. Multiple myeloma: New staging systems for diagnosis, prognosis and response evaluation

3. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

4. A monoclonal gammopathy precedes multiple myeloma in most patients

5. The significance of monoclonal gammopathy of undetermined significance

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Current knowledge on therapeutic, diagnostic, and prognostics applications of exosomes in multiple myeloma: Opportunities and challenges;Archives of Biochemistry and Biophysics;2024-06

2. Pierce into Structural Changes of Interactions Between Mutated Spike Glycoproteins and ACE2 to Evaluate Its Potential Biological and Therapeutic Consequences;International Journal of Peptide Research and Therapeutics;2021-12-16