How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin-Reference-Cited by-同舟云学术

How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin

Published:2020-05 Issue:7 Volume:14 Page:549-562
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Spoto Silvia¹,Legramante Jacopo M²³,Minieri Marilena⁴⁵,Fogolari Marta⁶,Terrinoni Alessandro⁴,Valeriani Emanuele⁷,Sebastiano Costantino¹,Bernardini Sergio⁴⁵,Ciccozzi Massimo⁸,Angeletti Prof S⁶^ORCID

Affiliation:

1. Internal Medicine Department, University Campus Bio-Medico of Rome, Italy

2. Emergency Department, Policlinico Tor Vergata, Roma, Italy

3. Department of Medical Systems, Università di Tor Vergata, Roma, Italy

4. Department of Experimental Medicine & Surgery, Università di Tor Vergata, Roma, Italy

5. Department of Laboratory Medicine, Policlinico Tor Vergata, Roma, Italy

6. Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy

7. Department of Internal Medicine ‘SS.ma Annunziata' Hospital, Chieti, Italy

8. Unit of Medical Statistics & Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy

Abstract

Aim: The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. Material & methods: A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit were included in the study. PCT and MR-proADM plasma concentrations and pneumonia severity index score were measured. Median values were compared by Mann–Whitney’s test. Receiver operating characteristic analysis and rank correlation were used to define the diagnostic and prognostic accuracy. Results: PCT confirmed the diagnostic role at values 0.08–0.10 ng/ml and MR-proADM the prognostic role for severe pneumonia. Significant correlation (p < 0.0001) between MR-proADM and pneumonia severity index score indicated expression of pneumonia severity. Conclusion: This combination of biomarkers presents a high positive predictive value in pneumonia diagnosis and prognosis.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0414

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