Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer-Reference-Cited by-同舟云学术

Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer

Published:2020-04 Issue:5 Volume:14 Page:353-369
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Mu Hai-Qi¹,Liang Zhi-Qiang²³,Xie Qi-Peng⁴,Han Wei⁵,Yang Sen¹,Wang Shuai-Bin¹,Zhao Cheng²³,Cao Ye-Min²³,He You-Hua¹,Chen Jian²³^ORCID

Affiliation:

1. Department of Urology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

2. Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

3. Shanghai TCM-Integrated Institute of Vascular Anomalies, Shanghai, China

4. Department of Laboratory Medicine, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

5. Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong, China

Abstract

Aim: Prostate cancer (PCa) is the sixth leading cause of cancer-related deaths in men throughout the world. This study aimed to investigate genes associated with the pathogenesis and prognosis of PCa. Materials & methods: Data of PCa cases were obtained from public datasets and were analyzed using an integrated bioinformatics strategy. Results: A total of 969 differential expression genes were identified. Moreover, GSE16560 and The Cancer Genome Atlas (TCGA) data showed a prognostic prompt function of the nine-gene signature, as well as in PCa with Gleason 7. Finally, majority of the nine hub genes were associated with drug sensitivity, mutational landscape, immune infiltrates and clinical characteristics of PCa. Conclusion: The nine-gene signature was correlated with drug sensitivity, mutational landscape, immune infiltrates, clinical characteristics and survival from PCa.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0318

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