Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma-Reference-Cited by-同舟云学术

Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma

Published:2019-09 Issue:13 Volume:13 Page:1093-1105
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zhao Ning-Hui¹,Qian Yu¹,Wu Chen-Si¹,Wang Jing-Wen¹,Fang Yu¹,Fan Xiao-Peng¹²,Gao Shuai¹,Fan Yu-Chen¹²,Wang Kai¹²³

Affiliation:

1. Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, PR China

2. Institute of Hepatology, Shandong University, Jinan 250012, PR China

3. Shenzhen Research Institute of Shandong University, Shenzhen 518000, PR China

Abstract

Aim: Natural killer cell receptor group 2D (NKG2D) plays an important role in the immune regulation of tumors. We speculate that DNA methylation are involved in the regulation of NKG2D gene. Methods: We investigated the methylation status of the NKG2D promoter in peripheral blood mononuclear cells of hepatocellular carcinoma (HCC) patients, chronic hepatitis B patients and healthy controls by methylation-specific PCR and the mRNA expression level was examined by real-time quantitative PCR. Results: The methylation frequency of NKG2D promoter in HCC patients was higher than that of chronic hepatitis B patients and healthy controls. NKG2D promoter methylation has a good predictive value for HCC diagnosis. Conclusion: NKG2D promoter methylation can be used as a noninvasive marker for detecting HCC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2019-0102

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