Association of Cyr61-cysteine-rich protein 61 and short-term mortality in patients with acute heart failure and coronary heart disease

Author:

Liu Chen12,Cao Yalin3,He Xin12,Zhang Chongyu12,Liu Jian4,Zhang Lili5,Wu Dexi12,Zhuang Xiaodong12,Xue Ruicong12,Huang Huiling12,Jiang Jingzhou12,Dong Bin12,Sun Yu12,Dong Yugang12,Zhao Jingjing12

Affiliation:

1. Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China

2. NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou 510080, PR China

3. Department of Cardiology, Guizhou Provincial People’s Hospital, Guiyang 550001, PR China

4. Department of Anesthesiology, Southern Medical University Nanfang Hospital, Guangzhou 510515, PR China

5. Department of Cardiology, Hainan General Hospital, Haikou 570311, PR China

Abstract

Aim: The protein CCN1/CYR61 exerts critical functions in myocardial ischemic injury. We sought to investigate the prognostic value of CCN1 in patients with acute heart failure (AHF) and coronary heart disease (CAD). Methodology: We prospectively enrolled 113 patients with AHF and CAD. Patients were followed for all-cause mortality during a 30-day follow-up. Logistic models were used to estimate the association of CCN1 concentrations with 30-day mortality. Results: In multivariate logistic regression model, CCN1 was a significant predictor of 30-day mortality independent of current markers. Enhanced Feedback for Effective Cardiac Treatment risk score was recommended as one of the selected multivariable risk scores to predict outcome in AHF. CCN1 improved risk stratification for all-cause mortality when added to the Enhanced Feedback for Effective Cardiac Treatment risk scores at 30 days. Conclusion: We found CCN1 is independently associated with 30-day mortality in patients with AHF and CAD.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

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