Resting functional connectivity and mild cognitive impairment in Parkinson’s disease. An electroencephalogram study

Author:

Carmona Arroyave Jairo Alexander12,Tobón Quintero Carlos Andrés12,Suárez Revelo Jasmín Jimena13,Ochoa Gómez John Fredy13,García Yamile Bocanegra12,Gómez Leonardo Moreno4,Pineda Salazar David Antonio125

Affiliation:

1. Neuroscience Group, Medical School, University of Antioquia, SIU, Calle 62 No. 52–59, Medellín, Colombia

2. Neuropsychology & Behavior Group (GRUNECO), Medical School, University of Antioquia, SIU – Área Asistencial, Calle 62 No. 52–59, Medellín, Colombia

3. Bioinstrumentation & Clinical Engineering Research Group (GIBIC), Bioengineering Program, University of Antioquia, Calle 70 No. 52–21, Medellín, Colombia

4. Neurology Unit, Pablo Tobón Uribe Hospital, Calle 78B No. 69–240, Medellín, Colombia

5. Neuropsychology & Behavior Group (GRUNECO), Psychology Department, University of San Buenaventura, Carrera 56 C No. 51–110, Medellín, Colombia

Abstract

Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI.

Publisher

Future Medicine Ltd

Subject

Clinical Neurology,Neurology

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