Epigenetic mechanisms in gastric cancer-Reference-Cited by-同舟云学术

Epigenetic mechanisms in gastric cancer

Published:2012-06 Issue:3 Volume:4 Page:279-294
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Gigek Carolina Oliveira¹,Chen Elizabeth Suchi²,Calcagno Danielle Queiroz²,Wisnieski Fernanda²,Burbano Rommel Rodriguez³,Smith Marilia Arruda Cardoso²

Affiliation:

1. Disciplina de Genética, Departamento de Morfologia e Genética, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Botucatu 740, Ed. Leitão da Cunha – 1° andar – CEP 04023-900, São Paulo, SP, Brazil.

2. Disciplina de Genética, Departamento de Morfologia e Genética, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Botucatu 740, Ed. Leitão da Cunha – 1° andar – CEP 04023-900, São Paulo, SP, Brazil

3. Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil

Abstract

Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. In conclusion, an epigenetic therapy might appear in the not too distant future.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi.12.22

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