Checkpoint inhibitors in bladder and renal cancers: results and perspectives-Reference-Cited by-同舟云学术

Checkpoint inhibitors in bladder and renal cancers: results and perspectives

Published:2015-12 Issue:12 Volume:7 Page:1259-1271
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Aoun Fouad¹,Kourie Hampig R²,Sideris Spyridon²,Roumeguère Thierry³,Velthoven Roland van¹,Gil Thierry²

Affiliation:

1. Department of Urology, Jules Bordet Institute, 1 Héger Bordet Street, 1000 Brussels, Belgium

2. Department of Oncology, Jules Bordet Institute, 1 Héger Bordet Street, 1000 Brussels, Belgium

3. Department of Urology, Erasme Hospital, Route de Lennik 808, 1070 Brussels, Belgium

Abstract

The field of immunotherapy in urinary malignancy is expanding in several directions and checkpoint inhibitors are leading the way. The aim of this report is to highlight the efficacy and safety profile of the two classes of molecules, anti-cytotoxic T-lymphocyte antigen-4 and anti-programmed death receptor-1/programmed death ligand type 1, that are under investigation and represent potential candidates to be used in the near future for the management of bladder and renal cell cancer. The preliminary results as well as the future perspectives of this novel immunotherapy are analyzed. Novel immune checkpoint targets are reviewed as well.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt.15.91

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