Rotavirus vaccines: current global impact and future perspectives

Author:

Burnett Eleanor1,Yen Catherine1,Tate Jacqueline E1,Parashar Umesh D1

Affiliation:

1. Division of Viral Disease, Centers for Disease Control & Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, USA

Abstract

As of May 2016, 81 countries have introduced Rotarix or RotaTeq rotavirus vaccines into their national immunization program. Despite initially slow uptake in some countries and differences in vaccine effectiveness (VE) between high-, low- and middle-income countries, impact of the vaccines has been swift and striking in all settings, with good VE against vaccine-type and nonvaccine-type strains. Newly published research indicates poor nutrition is associated with decreased VE and breastfeeding at the time of vaccination does not affect vaccine response. Vaccines in development and proposed alternate schedules also promise to address limitations of the current vaccines and optimize rotavirus disease prevention.

Publisher

Future Medicine Ltd

Subject

Virology

Reference61 articles.

1. PATH. Country introductions of rotavirus vaccines. http://sites.path.org/rotavirusvaccine/country-introduction-maps-and-spreadsheet/

2. WHO. Immunization coverage. www.who.int/mediacentre/factsheets/fs378/en/

3. Rotavirus vaccine introduction in the Americas: progress and lessons learned

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