Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer-Reference-Cited by-同舟云学术

Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer

Published:2019-02 Issue:5 Volume:15 Page:485-494
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Silva Gustavo T¹,Silva Larissy M²,Bergmann Anke²,Thuler Luiz CS²³

Affiliation:

1. Cancer Hospital I, National Cancer Institute, Rio de Janeiro, Brazil

2. Research Center, National Cancer Institute, Rio de Janeiro, Brazil

3. Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

Abstract

Aim: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival. Patients & methods: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan–Meier survival analysis and the risk of death were estimated. Results: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04–1.49; p = 0.013). Conclusion: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0613

Reference36 articles.

1. Global cancer statistics, 2012

2. Epidemiology of lung cancer in China

3. Mortality following bone metastasis and skeletal-related events among patients 65 years and above with lung cancer: A population-based analysis of U.S. Medicare beneficiaries, 1999-2006

4. Epidemiology and Treatment Costs of Bone Metastases from Lung Cancer: A French Prospective, Observational, Multicenter Study (GFPC 0601)

5. Cancer statistics, 2018

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Trends and Factors Affecting the Initiation of Denosumab and Zoledronic Acid among Patients with Metastatic Lung, Breast, and Prostate Cancer in the United States;2024-04-22

2. Effects of Patient-Controlled Transcutaneous Electrical Acupoint Stimulation on Cancer Induced Bone Pain Relief in Patients with Non-Small Cell Lung Cancer: Study Protocol for a Randomized Controlled Trial;Journal of Pain Research;2024-03

3. Short-term pain control after palliative radiotherapy for uncomplicated bone metastases: a prospective cohort study;Medical Oncology;2023-12-11

4. Prevalence and prognosis of bone metastases in common solid cancers at initial diagnosis: a population-based study;BMJ Open;2023-10

5. Incidence of Bone Metastases and Skeletal-Related Events in Patients With EGFR-Mutated NSCLC Treated With Osimertinib;JTO Clinical and Research Reports;2023-05