miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB-Reference-Cited by-同舟云学术

miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB

Published:2019-06 Issue:17 Volume:15 Page:2019-2028
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Tian Qi¹²,Sun He-Fen³,Wang Wen-Jing¹²,Li Qing¹²,Ding Jie⁴,Di Wen¹²⁵

Affiliation:

1. Department of Obstetrics & Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China

2. Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China

3. Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, 200030, PR China

4. Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China

5. State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, PR China

Abstract

Aim: miR-365b, a miRNA at chromosomal breakpoint, was often amplified and upregulated in human hepatocellular carcinoma (HCC). However, the role of miR-365b dysregulation remains unclear. Materials & methods: miR-365b function assays and its target gene analyses were performed. Results: We revealed that miR-365b promoted HCC cell motility and spreading. Furthermore, SGTB was found to be a downstream target of miR-365b, and knockdown of the SGTB gene could mimic the effect of miR-365b in hastening HCC cell migration and invasion. Conclusion: These results imply that miR-365b plays a tumor-promoting role in HCC by suppressing SGTB expression, offering novel potential targets for the treatment of HCC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0676

Reference36 articles.

1. Small non-coding RNA and cancer

2. A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study

3. Small molecule with big role: MicroRNAs in cancer metastatic microenvironments

4. Global cancer statistics, 2012

5. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA

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