High Oct4 predicted worse prognosis of right-sided colon cancer patients-Reference-Cited by-同舟云学术

High Oct4 predicted worse prognosis of right-sided colon cancer patients

Published:2018-09 Issue:22 Volume:14 Page:2279-2291
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Wang Qing-hua¹,Zhang Min²,Shi Chun-tao³,Xie Jun-jie¹,Chen Fang⁴,Shi Qi-feng⁵,Cheng Jie³,Wang Hao-nan⁶

Affiliation:

1. Digestive Department, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, PR China

2. Department of General Surgery, Wuxi Second Hospital of Traditional Chinese Medicine, Wuxi, Jiangsu 214000, PR China

3. Department of General Surgery, Wuxi Xishan People's Hospital, Wuxi, Jiangsu 214000, PR China

4. Pathology Department, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, PR China

5. Pathology Department, Wuxi Xishan People's Hospital, Wuxi, Jiangsu 214000, PR China

6. Oncology Department, Wuxi Fifth People's Hospital, Wuxi, Jiangsu 214000, PR China

Abstract

Aim: This present study was aimed to compare the role of Oct4 in left-sided colon cancer (LCC) with right-sided colon cancer (RCC). Patients & methods: One hundred and fifty one pathology specimens, 68 frozen-thawed tumors and cell lines were used to evaluate the role of Oct4 in LCC and RCC through immunohistochemistry, western blot and real-time quantitative PCR. Results: In LCC, positive expression of Oct4 was positively related to differentiation and Dukes stage (p < 0.01). Only in RCC, Oct4 expression was also positively related to lymphatic invasion and survival rates of ‘negative group’ were significantly higher. Conclusion: In summary, Oct4 was related to tumor differentiation and later Dukes stage in colon cancer, and was correlated with invasion of lymphatic only in RCC. In addition, Oct4 was a potential prognostic indicator in RCC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0046

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