High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

Abstract

Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18–3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54–5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.