The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry-Reference-Cited by-同舟云学术

The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry

Published:2018-11 Issue:26 Volume:14 Page:2713-2723
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Merante Serena¹²,Ferretti Virginia V¹,Elena Chiara¹,Brazzelli Valeria³,Zanotti Roberta⁴,Neri Iria⁵,Magliacane Diomira⁶,Belloni Fortina Anna⁷,Ingeborg Forer⁸,Pastorello Elide A⁹,Pieri Lisa¹⁰,Papayannidis Cristina¹¹,Mauro Marina¹²,Grifoni Federica¹³,Minelli Roberto¹⁴,Guggiari Elena¹⁵,Difonzo Elisa¹⁶,Bocchia Monica¹⁷,Caroppo Francesca⁷,Di Nuzzo Sergio¹⁸,Elli Elena Maria¹⁹,Rondoni Michela²⁰,Ciccocioppo Rachele²¹,Di Stefano Michele²²,Bossi Grazia²³,Boveri Emanuela²⁴,Bonadonna Patrizia²⁵,Giona Fiorina²⁶,Valent Peter²⁷²⁸,Triggiani Massimo⁶

Affiliation:

1. Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

2. Hematology Department, James Cook University Hospital, South Tees Trust (NHS), Middlesbrough, UK

3. Dermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

4. Hematology, Policlinico GB Rossi, Verona, Italy

5. Dermatology, Department of Experimental, Diagnostic & Specialty Medicine, University of Bologna, Bologna, Italy

6. Immunology & Allergology, University of Salerno, Salerno, Italy

7. Pediatric Dermatology, DIMED, University of Padua, Padua, Italy

8. Dermatololgy & Venerology, Hospital of Brunico, Italy

9. Allergology & Immunology, Niguarda Hospital, Milano, Italy

10. Center of Research & Innovation of Myeloproliferative Neoplasms (CRIMM), Careggi University Hospital/University of Florence, Florence, Italy

11. Hematology, University of Bologna, Bologna, Italy

12. Allergy Unit, Sant'Anna Hospital, Como, Italy

13. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy

14. Pediatric, University of Cagliari, Cagliari, Italy

15. Hematology, San Raffaele Hospital, Milano, Italy

16. Dermatology, University of Florence, Florence, Italy

17. Hematology, University of Siena, Siena, Italy

18. Dermatology, University of Parma, Parma, Italy

19. Divisione di Ematologia, Ospedale San Gerardo, ASST Monza, Italy

20. Hematology, Ospedale di Cesena, Cesena, Italy

21. Gastroenterology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy

22. Internal Medicine, IRCCS, Policlinico San Matteo, Pavia, Italy

23. Pediatric Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

24. Pathology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, University of Pavia, Italy

25. Allergology, Ospedale Civile Maggiore, Verona, Italy

26. Ematologia, Sapienza Università di Roma, Azienda Policlinico Umberto I Roma, Italy

27. Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria

28. Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria

Abstract

Aim: We collected ‘real-life’ data on the management of patients with mastocytosis in the Italian Mastocytosis Registry. Methods: Six hundred patients diagnosed with mastocytosis between 1974 and 2014 were included from 19 centers. Results: Among adults (n = 401); 156 (38.9%) patients were diagnosed with systemic mastocytosis. In 212 adults, no bone marrow studies were performed resulting in a provisional diagnosis of mastocytosis of the skin. This diagnosis was most frequently established in nonhematologic centers. In total, 182/184 pediatric patients had cutaneous mastocytosis. We confirmed that in the most patients with systemic mastocytosis, serum tryptase levels were >20 ng/ml and KIT D816V was detectable. Conclusion: The Italian Mastocytosis Registry revealed some center-specific approaches for diagnosis and therapy. Epidemiological evidence on this condition is provided.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0291

Reference26 articles.

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