Updating the 2011 International Association for the Study of Lung Cancer classification of lung adenocarcinoma: main priorities and implications for clinicians

Abstract

SUMMARY:  The classification of adenocarcinoma was revised by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society in 2011. In the face of advances of medical therapy in advanced stage disease, these groups sought to improve prognostication and to standardize reporting protocols. A discussion of recent alterations in terminology is undertaken. Included with this is clarification of terminology used small biopsy and cytology specimens. In addition, it will be discussed how an architectural-based classification can be used to assess prognosis and how this applies staging and potential patient management. Several studies have confirmed the effectiveness and reproducibility of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification on lung adenocarcinoma. In addition, there is increasing evidence of clinical application in early stage lung adenocarcinoma. While there may be potential revision in the future, the classification provides better and more standardized information for both clinicians and researchers.