Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field-Reference-Cited by-同舟云学术

Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field

Published:2021-04 Issue:10 Volume:16 Page:787-800
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Yang Seung-Hyun¹²^ORCID,Kang Byunghoon³,Choi Yuna²,Rho Hyun Wook²,Son Hye Young²⁴^ORCID,Huh Yong-Min²⁴⁵⁶^ORCID

Affiliation:

1. Interdisciplinary Program in Nanomedical Science & Technology, Nanomedical National Core Research Center, Yonsei University, Seoul 03722, Republic of Korea

2. Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

3. BioNanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Republic of Korea

4. Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

5. Department of Biochemistry & Molecular Biology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

6. YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

Abstract

Aim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. Methods: U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo. Results: LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. Conclusion: When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.

Funder

Korea Research Institute of Standards and Science

National Research Foundation of Korea

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2020-0399

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