Cancer nanomedicine developed from total human serum: a novel approach for making personalized nanomedicine

Author:

Thayath Jyotsna1ORCID,Pavithran Keechilat2ORCID,Nair Shantikumar V1ORCID,Koyakutty Manzoor1ORCID

Affiliation:

1. Centre for Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, 682041, India

2. Department of Medical Oncology & Hematology, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India

Abstract

Aim: To develop a method for making total serum nanoparticles (TSN) loaded with cytotoxic chemodrugs for cancer therapy. Materials & methods: TSN loaded with paclitaxel (PTX) or piperlongumine (PL) were prepared using high-pressure homogenization and tested for immunogenicity in healthy animals and antitumor properties in pancreatic cancer xenograft models. Results: TSN-PL nanoparticles of average size 104 nm and encapsulation efficiency approximately 50% showed enhanced dose-dependent cytotoxicity compared with TSN-PTX or clinically used combination of gemcitabine and nano-PTX in two pancreatic cell lines. Significant antitumor efficacy was also established in the pancreatic xenograft model. Conclusion: We developed a unique method of converting total blood serum into chemo drug-loaded nanoparticles and demonstrated its efficacy in vitro and in vivo.

Funder

Nanobiotechnology task force, Department of Biotechnology (DBT) Govt of India

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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