The importance of spheroids in analyzing nanomedicine efficacy-Reference-Cited by-同舟云学术

The importance of spheroids in analyzing nanomedicine efficacy

Published:2020-06 Issue:15 Volume:15 Page:1513-1525
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Mó Inês¹,Sabino Ivo J¹,Melo-Diogo Duarte de¹,Lima-Sousa Rita¹,Alves Cátia G¹,Correia Ilídio J¹²^ORCID

Affiliation:

1. CICS-UBI – Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506, Covilhã, Portugal

2. CIEPQPF – Departamento de Engenharia Química, Universidade de Coimbra, 3030-790, Coimbra, Portugal

Abstract

The use of nanomedicines for cancer treatment holds a great potential due to their improved efficacy and safety. During the nanomedicine preclinical in vitro evaluation stage, these are mainly tested on cell culture monolayers. However, these 2D models are an unrealistic representation of the in vivo tumors, leading to an inaccurate screening of the candidate formulations. To address this problem, spheroids are emerging as an additional tool to validate the efficacy of new therapeutics due to the ability of these 3D in vitro cancer models to mimic the key features displayed by in vivo solid tumors. In this review, the application of spheroids for the evaluation of nanomedicines’ physicochemical properties and therapeutic efficacy is discussed.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2020-0054

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