Nanotherapeutic systems for delivering cancer vaccines: recent advances

Author:

Beg Sarwar1ORCID,Alharbi Khalid S2,Alruwaili Nabil K3,Alotaibi Nasser Hadal4,Almalki Waleed H5,Alenezi Sattam K6,Altowayan Waleed M7,Alshammari Mohammed S8,Rahman Mahfoozur9

Affiliation:

1. Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India

2. Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia

3. Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia

4. Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia

5. Department of Pharmacology & Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

6. Department of Pharmacology & Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia

7. Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia

8. Department of Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia

9. Department of Pharmaceutical Sciences, SIHAS, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, India

Abstract

With an increase in the global burden of cancer-related deaths, the quest for developing new therapeutic solutions has taken momentum. In this regard, the idea of using cancer vaccines came to existence approximately 30 years ago, where gene therapy interventions have shown significant improvement in the therapeutic outcomes against several types of cancers. Cancer vaccines usually encounter a number of challenges with limited targeting ability to the tumors. Nanocarriers have been studied as a technological innovation for tumor targeting of gene therapeutics. This article provides a critical insight into the recent progress made in nanotherapeutic strategies for genetic vaccine delivery for treatment against various types of cancers. Moreover, the article intends to provide a summary of the research work being done on this topic.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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