Cerium oxide nanoparticles: a ‘radical’ approach to neurodegenerative disease treatment

Author:

Naz Shuguftha1,Beach James1,Heckert Blaze1,Tummala Tanuja1,Pashchenko Oleksandra1,Banerjee Tuhina1,Santra Santimukul1

Affiliation:

1. Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, 1701 S. Broadway Street, Pittsburg, KS 66762, USA

Abstract

Despite advances in understanding the factors that cause many neurodegenerative diseases (NDs), no current therapies have yielded significant results. Cerium oxide nanoparticles (CeONPs) have recently emerged as therapeutics for the treatment of NDs due to their antioxidant properties. This report summarizes the recent findings regarding CeONPs in treatment of various NDs, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis. Interest in CeONPs as a potential nanomedicine for NDs has increased due to: their ability to alter signaling pathways, small diameter allowing passage through the blood–brain barrier and scavenging of reactive oxygen species. Due to these properties, CeONPs could eventually revolutionize existing treatments for NDs.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Reference62 articles.

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