Combining nanoscale magnetic nimodipine liposomes with magnetic resonance image for Parkinson's disease targeting therapy-Reference-Cited by-同舟云学术

Combining nanoscale magnetic nimodipine liposomes with magnetic resonance image for Parkinson's disease targeting therapy

Published:2017-02 Issue:3 Volume:12 Page:237-253
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Ji Bingshuo¹,Wang Meili¹,Gao Dawei¹²,Xing Shanshan¹,Li Lei¹,Liu Lanxiang³,Zhao Min³,Qi Ximing³,Dai Kun¹

Affiliation:

1. Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China

2. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China

3. Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China

Abstract

Aim: To enhance drug targeting and blood–brain barrier penetration for Parkinson's disease (PD), a novel nanoscale magnetic nimodipine (NMD) delivery system was designed and prepared. Materials & methods: The PD rats were established and treated with free NMD or Fe3O4-modified NMD liposomes (Fe3O4-NMD-lips). Then, factional anisotropy values were measured by MRI to evaluate therapy efficacy. Results: Fe3O4-NMD-lips showed the best neuroprotective effect, and the NMD concentration of lesions was 2.5-fold higher in Fe3O4-NMD-lips group than that of free NMD group. Conclusion: These results demonstrated that the magnetic drug system had a great potential to cross the blood–brain barrier and provided a noninvasive and effective therapeutic strategy for PD.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2016-0267

Reference62 articles.

1. Parkinson's Disease

2. Parkinson's disease: 10 years of progress, 1997-2007

3. Life cycle assessment of a national policy proposal – The case of a Swedish waste incineration tax

4. The discovery of dopamine deficiency in the parkinsonian brain

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