Therapeutic PEG-ceramide nanomicelles synergize with salinomycin to target both liver cancer cells and cancer stem cells-Reference-Cited by-同舟云学术

Therapeutic PEG-ceramide nanomicelles synergize with salinomycin to target both liver cancer cells and cancer stem cells

Published:2017-05 Issue:9 Volume:12 Page:1025-1042
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Wang Meiping¹,Xie Fangyuan¹²,Wen Xikai¹,Chen Han³,Zhang Hai²,Liu Junjie¹,Zhang He¹,Zou Hao¹,Yu Yuan¹,Chen Yan¹,Sun Zhiguo¹,Wang Xinxia²,Zhang Guoqing²,Yin Chuan⁴,Sun Duxin⁵,Gao Jie¹⁵,Jiang Beige⁶,Zhong Yanqiang¹,Lu Ying¹

Affiliation:

1. Department of Pharmaceutical Sciences, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China

2. Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, 225 Changhai Road, Shanghai 200438, China

3. Department of General Surgery, 411 Hospital of Chinese People's Liberation Army, 15 East Jiangwan Road, Shanghai 200081, China

4. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

5. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA

6. Third Department of HepaticSurgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai 200438, China

Abstract

Aim: Salinomycin (SAL)-loaded PEG-ceramide nanomicelles (SCM) were prepared to target both liver cancer cells and cancer stem cells. Materials & methods: The synergistic ratio of SAL/PEG-ceramide was evaluated to prepare SCM, and the antitumor activity of SCM was examined both in vitro and in vivo. Results: SAL/PEG-ceramide molar ratio of 1:4 was chosen as the synergistic ratio, and SCM showed superior cytotoxic effect and increased apoptosis-inducing activity in both liver cancer cells and cancer stem cells. In vivo, SCM showed the best tumor inhibitory effect with a safety profile. Conclusion: Thus, PEG-ceramide nanomicelles could serve as an effective and safe therapeutic drug carrier to deliver SAL into liver cancer, opening up the avenue of using PEG-ceramide as therapeutic drug carriers.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2016-0408

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