Bendamustine as a model for the activity of alkylating agents

Author:

Apostolopoulos Christos1,Castellano Leandro1,Stebbing Justin1,Giamas Georgios2

Affiliation:

1. Imperial College School of Medicine, Department of Medical Oncology, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK

2. Imperial College School of Medicine, 6th Floor MRC Cyclotron Building, Imperial College, Hammersmith Hospital, London, W12 0NN, UK.

Abstract

Attempts to administer personalized standard cytotoxic chemotherapy based on individual patient characteristics have been disappointing. Alkylating agents are one of the oldest classes of anticancer medicine with a wide variety of molecular actions and thus the potential for broad utility. Bendamustine hydrochloride, a new addition to this class, was previously developed in the 1960s and has now been trialled in hematological malignancies and many solid tumor types as monotherapy or in combination with the known standard of care. It appears to occupy a particular role in resistant or refractory hematological disease and it was approved by the US FDA for the treatment of chronic lymphocytic leukemia in March 2008. Further trials will reveal whether it is likely to become incorporated into front-line regimens in non-Hodgkin’s lymphoma and other malignancies.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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