Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Author:

Jiang Yicheng1,Huo Zhiyi1,Qi Xiaole12,Zuo Tongmei2,Wu Zhenghong1

Affiliation:

1. Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, 210009, PR China

2. Industrial Technology Innovation Platform, Zhejiang Center for Safety Study of Drug Substances, Hangzhou, 310018, China

Abstract

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing irreversible damage. Copper can induce multiple forms of cell death, including apoptosis and autophagy, through various mechanisms, including reactive oxygen species accumulation, proteasome inhibition, and antiangiogenesis. Hence, copper in vivo has attracted tremendous attention and is in the research spotlight in the field of tumor treatment. This review first highlights three typical forms of copper’s antitumor mechanisms. Then, the development of diverse biomaterials and nanotechnology allowing copper to be fabricated into diverse structures to realize its theragnostic action is discussed. Novel copper complexes and their clinical applications are subsequently described.

Funder

Double First-Class Innovation Team of China Pharmaceutical University

National Mega-project for Innovative Drugs

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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