Expanding the arsenal against pulmonary diseases using surface-functionalized polymeric micelles: breakthroughs and bottlenecks

Author:

Khursheed Rubiya1ORCID,Paudel Keshav R2ORCID,Gulati Monica13ORCID,Vishwas Sukriti1ORCID,Jha Niraj Kumar4ORCID,Hansbro Philip M2ORCID,Oliver Brian G56ORCID,Dua Kamal37,Singh Sachin Kumar13ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India

2. Centre of Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, 2007, Australia

3. Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia

4. Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32–34 Knowledge Park III Greater Noida, Uttar Pradesh, 201310, India

5. Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, 2007, Australia

6. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney 2007, Australia

7. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia

Abstract

Pulmonary diseases such as lung cancer, asthma and tuberculosis have remained one of the common challenges globally. Polymeric micelles (PMs) have emerged as an effective technique for achieving targeted drug delivery for a local as well as a systemic effect. These PMs encapsulate and protect hydrophobic drugs, increase pulmonary targeting, decrease side effects and enhance drug efficacy through the inhalation route. In the current review, emphasis has been placed on the different barriers encountered by the drugs given via the pulmonary route and the mechanism of PMs in achieving drug targeting. The applications of PMs in different pulmonary diseases have also been discussed in detail.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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