A nano-phytochemical ophthalmic solution for marked improvement of corneal wound healing in healthy or diabetic mice

Abstract

Aim: To formulate a novel nano-phytochemical ophthalmic solution to promote corneal wound healing. Methods: Dipotassium glycyrrhizinate (DG) and palmatine (PAL) were used to formulate this formulation marked as DG–PAL, and its efficacy and mechanisms for promoting corneal wound healing were evaluated in mice. Results: DG–PAL was easily fabricated with excellent physical profiles. In in vivo efficiency evaluations, DG–PAL demonstrated an excellent promoting effect on corneal epithelial/nerve wound healing in both healthy and diabetic mice. These effects were involved in the DG–PAL-induced decreased expression levels of HMGB1 and its signaling-related factors in the corneas and trigeminal neurons of the healthy or diabetic mice. Conclusion: DG–PAL possibly represents a promising ophthalmic solution for promoting corneal wound healing.