The effect of AS1411 surface density on the tumor targeting properties of PEGylated silver nanotriangles-Reference-Cited by-同舟云学术

The effect of AS1411 surface density on the tumor targeting properties of PEGylated silver nanotriangles

Published:2022-02 Issue:5 Volume:17 Page:289-302
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Cao Yuyu¹,Yang Huiquan¹,Li Dongdong¹,Li Fan¹,Ma Jing¹,Liu Peidang¹²^ORCID

Affiliation:

1. School of Medicine, Southeast University, Nanjing, Jiangsu, People’s Republic of China

2. Jiangsu Key Laboratory for Biomaterials & Devices, Southeast University, Nanjing, Jiangsu, People’s Republic of China

Abstract

Aim: To determine the optimal AS1411 density on polyethylene glycol (PEG)ylated silver nanotriangles (PNTs) for targeting breast cancer cells. Methods: PNTs modified with different AS1411 densities (ANTs) were constructed, characterized and evaluated for their targeting properties in breast cancer cells and a mouse model of breast cancer. Results: AS1411 was successfully conjugated to PNTs. The accumulation and cellular uptake of 10-ANTs were the highest. 10-ANTs plus near-IR laser irradiation displayed the greatest inhibitory effect on cell viability. However, 5-ANTs had the highest accumulation in tumor tissues. When combined with NIR laser, 5-ANTs exhibited the best in vivo photothermal therapy effect. Conclusion: The optimal AS1411 densities at the cellular and animal levels were 10% and 5%, respectively.

Funder

National Key Basic Research Program of China

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0304

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