Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model-Reference-Cited by-同舟云学术

Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model

Published:2022-05 Issue:11 Volume:17 Page:753-764
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Surve Chaitali¹²^ORCID,Banerjee Ananya³^ORCID,S Anupriya³^ORCID,Chakraborty Rajasree³^ORCID,Kumar Dhiraj⁴^ORCID,Butti Ramesh⁴^ORCID,Gorain Mahadeo⁴^ORCID,Parida Sabyasachi⁵^ORCID,Kundu Gopal C³⁴^ORCID,Shidhaye Supriya¹,Patnaik Srinivas³

Affiliation:

1. Department of Pharmaceutics, Vivekanand Education Society's College of Pharmacy, Mumbai, India

2. Faculty of Pharmacy, Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India

3. School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India

4. National Centre for Cell Science (NCCS), NCCS Complex, Pune, Maharashtra, India

5. Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha 24, India

Abstract

Aim: To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials & methods: MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs. Results: The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC50 of methotrexate and a sizable reduction in tumor burden. Conclusion: MTX-NP oral formulation can be a promising candidate in breast cancer treatment with improved cellular uptake and in vivo efficacy.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0446

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