Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression and cytotoxicity of nano-quercetin-Reference-Cited by-同舟云学术

Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression and cytotoxicity of nano-quercetin

Published:2021-09 Issue:22 Volume:16 Page:1937-1961
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Mohammed Hamdoon A¹²^ORCID,Sulaiman Ghassan M³^ORCID,Anwar Sahar S³,Tawfeeq Amer T⁴,Khan Riaz A¹^ORCID,Mohammed Salman A A⁵,Al-Omar Mohsen S¹⁶,Alsharidah Mansour⁷,Rugaie Osamah Al⁸,Al-Amiery Ahmed A⁹¹⁰

Affiliation:

1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia

2. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, 11371, Egypt

3. Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad,10066, Iraq

4. Department of Molecular Biology, Iraqi Center for Cancer and Medical Genetics Research, Mustansiriyah University, PO Box 14022, Baghdad, Iraq

5. Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia

6. Medicinal Chemistry and Pharmacognosy Department, Faculty of Pharmacy, JUST, Irbid, 22110, Jordan

7. Department of Physiology, College of Medicine, Qassim University, Qassim, 51452, Kingdom of Saudi Arabia

8. Department of Basic Medical Sciences, College of Medicine and Medical Sciences, Qassim University, Unaizah, PO Box 991, Qassim, 51911, Saudi Arabia

9. Unit of Applied Sciences Research, Department of Applied Science, University of Technology, Baghdad,10066, Iraq

10. Department of Chemical and Process Engineering, University of Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia

Abstract

Aims: To evaluate the anti breast-cancer activity, biocompatibility and toxicity of poly(d,l)-lactic- co-glycolic acid (PLGA)-encapsulated quercetin nanoparticles (Q-PLGA-NPs). Materials & methods: Quercetin was nano-encapsulated by an emulsion–diffusion process, and the nanoparticles were fully characterized through Fourier transform infrared spectroscopy, x-ray diffractions, FESEM and zeta-sizer analysis. Activity against CAL51 and MCF7 cell lines were assessed by DNA fragmentation assays, fluorescence microscopy, and acridine-orange, and propidium-iodide double-stainings. Biocompatibility towards red blood cells and toxicity towards mice were also explored. Results: The Q-PLGA-NPs exhibited apoptotic activity against the cell lines. The murine in vivo studies showed no significant alterations in the liver and kidney's functional biomarkers, and no apparent abnormalities, or tissue damages were observed in the histological images of the liver, spleen, lungs, heart and kidneys. Conclusion: The study established the preliminary in vitro efficacy and in vivo safety of Q-PLGA-NPs as a potential anti-breast cancer formulation.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0070

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