Photodynamic therapy-mediated extirpation of cutaneous-resistant dermatophytosis with Ag@ZnO nanoparticles: an efficient therapeutic approach for onychomycosis-Reference-Cited by-同舟云学术

Photodynamic therapy-mediated extirpation of cutaneous-resistant dermatophytosis with Ag@ZnO nanoparticles: an efficient therapeutic approach for onychomycosis

Published:2022-02 Issue:4 Volume:17 Page:219-236
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Ghaemi Behnaz¹^ORCID,Hashemi Seyed Jamal²³,Kharrazi Sharmin¹^ORCID,Moshiri Arfa⁴⁵^ORCID,Kargar Jahromi Hossein⁶,Amani Amir⁷⁸

Affiliation:

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, 1417755469, Iran

2. Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences,Tehran, 1417755469, Iran

3. Food Microbiology Research Centre, Tehran University of Medical Sciences, Tehran, 1417755469, Iran

4. Microbiology Research Centre, Pasteur Institute of Iran, Tehran, 1417755469, Iran

5. Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy

6. Research Centre for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran

7. Natural Products & Medicinal Plants Research Centre, North Khorasan University of Medical Sciences, Bojnurd, Iran

8. Medical Biomaterial Research Centre, Tehran University of Medical Sciences, Tehran, 1417755469, Iran

Abstract

Aim: The aim of this study was to determine whether photodynamic therapy of resistant onychomycosis with Ag@ZnO nanoparticles can promote the treatment procedure and extirpates the recurrence of fungal infection. Methods: Ag@ZnO nanoparticles (NPs) under UVB-radiation were applied to treat T. rubrum and T. mentagrophytes in vitro through photodynamic therapy. In vivo therapeutic efficacy, biocompatibility and biodistribution of Ag@ZnO NPs were studied. Results: 40 μg/ml of UVB-activated Ag@ZnO NPs showed 100% antifungal activity against dermatophytosis in vitro and in vivo followed by complete growth prevention by degeneration of spores and mycelium after 180 days, while posed biocompatibility. Conclusion: This study showed the superiority of photodynamic therapy with Ag@ZnO NPs followed by proper regeneration of the skin with Zinc ion of the shell.

Funder

Tehran University of Medical Sciences and Health Services

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0138

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