γ-irradiation from radiotherapy improves the virulence potential of Candida tropicalis-Reference-Cited by-同舟云学术

γ-irradiation from radiotherapy improves the virulence potential of Candida tropicalis

Published:2017-12 Issue:16 Volume:12 Page:1467-1486
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

da Silva Eliane M¹,Kischkel Brenda¹,Shinobu-Mesquita Cristiane S¹,Bonfim-Mendonça Patrícia S¹,Mansano Elaine SB¹,da Silva Marcos A²,Barbosa Jéssica F²,Fiorini Adriana³,Hernandes Luzmarina¹,Furlaneto Marcia C⁴,Svidzinski Terezinha IE¹

Affiliation:

1. Department of Clinical Analysis & Biomedicine/Postgraduate Program in Biosciences & Pathophysiology, Centro de Ciências da Saúde, Universidade Estadual de Maringá, Maringá, Paraná, Avenida Colombo, 5790, Maringá, PR, CEP 87020-900, Brazil

2. Sant'ana Radiation Oncology Center of Maringá, Paraná, Brazil

3. Department of Microbiology, Universidade Federal do Paraná, Setor Palotina, Paraná, Brazil

4. Department of Microbiology, Universidade Estadual de Londrina, Londrina, Paraná, Brazil

Abstract

Aim: To evaluate if radiation used in radiotherapy can cause changes in the virulence potential of Candida tropicalis ATCC 750. Materials & methods: C. tropicalis was exposed in vitro to identical dose and scheme of irradiation would be used in patients with head and neck cancer. Some virulence parameters were analyzed before and after irradiation. Results: Colony morphologies were irreversibly affected by irradiation. Increase in growth rate, filamentation, adhesion on cell lines and phagocytosis process were also observed. Overall the irradiated C. tropicalis cells became more efficient at causing systemic infection in mice. Conclusion: γ-radiation induced important changes in C. tropicalis increasing its virulence profile, which could directly affect the relationship between yeasts and hosts.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2017-0137

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