Histone acetyltransferase encoded by NGG1 is required for morphological conversion and virulence of Candida albicans

Author:

Li De-Dong123,Fuchs Beth Burgwyn2,Wang Yan3,Huang Xiao-Wen24,Hu Dan-Dan3,Sun Yan1,Chai Dong1,Jiang Yuan-Ying3,Mylonakis Eleftherios2

Affiliation:

1. Clinical Pharmacy Center, Department of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China

2. Division of Infectious Disease, Rhode Island Hospital, Alpert Medical School & Brown University, RI 02903, USA

3. New Drug Research & Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

4. Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China

Abstract

Aim: To assess the function of Ngg1 in Candida albicans and reveal the role of NGG1 in the morphological conversion and virulence of C. albicans. Materials & methods: C. albicans NGG1 gene was deleted in the wild-type strain SC5314 and the function of Ngg1 was assessed by western blot analysis. The phenotypes and the virulence of the ngg1 mutants were examined. Microarray analysis was performed to explore the mechanism. Results: The ngg1 mutants attenuated acetylated histone H3, obviously reduced filamentous growth and showed significantly diminished pathogenicity in all the infection models. Conclusion: This study suggested the histone acetyltransferase activity of C. albicans Ngg1 and revealed the important role of NGG1 in morphological conversion and virulence of C. albicans. [Formula: see text]

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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